DMD # 5785 1 In Vitro Human Naphthalene Metabolism

DMD#5785 In Vitro Metabolism of Naphthalene by Human Liver Microsomal Cytochrome P450 enzymes

The polycyclic aromatic hydrocarbon naphthalene is an environmental pollutant, a component of jet fuel and, since 2000, has been reclassified as a potential human carcinogen. Few studies of the in vitro human metabolism of naphthalene are available and these focus primarily on lung metabolism. The current studies were performed to characterize naphthalene metabolism by human cytochromes P450 (C...

In vitro metabolism of naphthalene by human liver microsomal cytochrome P450 enzymes.

The polycyclic aromatic hydrocarbon naphthalene is an environmental pollutant, a component of jet fuel, and, since 2000, has been reclassified as a potential human carcinogen. Few studies of the in vitro human metabolism of naphthalene are available, and these focus primarily on lung metabolism. The current studies were performed to characterize naphthalene metabolism by human cytochromes P450....

DMD#10439 INHIBITION OF THE HUMAN LIVER MICROSOMAL AND HUMAN CYTOCHROME P450 1A2 and 3A4 METABOLISM OF ESTRADIOL BY DEPLOYMENT-RELATED AND OTHER CHEMICALS

A list of non-standard abbreviations: DEET-N,N-diethyl-m-toluamide E2-estradiol TST-testosterone HLM-human liver microsomes CYP-cytochrome P450 HPLC-high performance liquid chromatography This article has not been copyedited and formatted. The final version may differ from this version. DMD#10439 Abstract Cytochrome P450s (CYPs) are major catalysts in metabolism of xenobiotics and endogenous su...

In Vitro Human Naphthalene Metabolism

Characterization of the binding of drugs to human intestinal fatty acid binding protein (IFABP): potential role of IFABP as an alternative to albumin for in vitro-in vivo extrapolation of drug kinetic parameters.

This work characterized for the first time the binding of acidic, neutral, and basic drugs to human intestinal fatty acid binding protein (IFABP) and, for comparison, to bovine serum albumin (BSA). In addition, the study investigated whether IFABP can substitute for BSA as a constituent in incubations of human liver microsomes (HLMs) in in vitro-in vivo extrapolation (IV-IVE) studies. Each mole...